Osteo-D Max is indicated for the treatment of conditions such as osteoporosis, hypoparathyroidism, rickets, osteomalacia, vitamin D deficiency, pseudohypoparathyroidism, and familial hypophosphatemia.
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Vitamin D3 deficiency may occur in individuals with limited sunlight exposure or insufficient dietary intake. Vitamin D3 is vital for the proper absorption of calcium and phosphate, essential for maintaining healthy bones and teeth and preventing conditions like rickets, osteomalacia, and osteoporosis. It also plays a crucial role in preventing pre-eclampsia during pregnancy and is important for infant development during breastfeeding. Vitamin D3 additionally helps boost immunity.
Cholecalciferol [Vitamin D3]
The safety and efficacy of Vitamin D3 in children under 12 years have not been established.
Side effects are rare but may include anorexia, fatigue, nausea, vomiting, diarrhea, constipation, weight loss, excessive urination, sweating, headaches, thirst, dizziness, and elevated calcium and phosphate levels in blood and urine.
Overdose Effects
Excessive intake can lead to hypervitaminosis D.
Vitamin D3, in its active form (Calcitriol), works by binding to Vitamin D receptors (VDRs), which are found in various tissues throughout the body. Vitamin D3 has a half-life of around 50 days due to its fat-soluble nature. It is absorbed in the small intestine and binds to specific α-globulins before being transported to the liver. In the liver, it is converted to 25-hydroxy Vitamin D3 (Calcidiol), which is further hydroxylated in the kidneys to 1,25-dihydroxy Vitamin D3 (Calcitriol), the active form responsible for enhancing calcium absorption. Unmetabolized Vitamin D3 is stored in fat and muscle tissues and excreted in the feces and urine.
This medication can be taken with or without food.
Colecalciferol is contraindicated in conditions associated with hypercalcemia and in patients with known hypersensitivity to Colecalciferol or any of its components. It is also contraindicated in cases of vitamin D toxicity.
Studies indicate that doses up to 4000 IU are safe during pregnancy. The recommended daily intake for pregnant women is 400 IU, but higher doses may be necessary in cases of deficiency. Vitamin D3 and its metabolites are excreted in breast milk. While no cases of overdose in infants due to maternal intake have been reported, practitioners should consider the total Vitamin D3 intake for both mother and child when prescribing.
Caution is advised for people with high levels of calcium or phosphorus, heart problems, or kidney disease. Vitamin D should be taken with sufficient calcium and magnesium. When calcium levels are low, the parathyroid gland produces parathyroid hormone (PTH), which activates vitamin D and mobilizes calcium from bones to maintain vital functions, such as neutralizing body acidity. During lactation, vitamin D passes into breast milk, so it should be used with caution.
Store below 30º C, away from light and moisture. Keep out of reach of children.
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